What to Obtain by Practicing Mindfulness Regularly

Sometimes dealing with the success is not something easy since you need to deal with yourself. It is a good idea finding lots of ways and tries so many things in getting the solution for such the various problems in reaching the success. It may happen caused by several possible factors including the factors inside you. Perhaps you often feel hard to focus on what you are doing, for example in your business. It may also be the obstacle in reaching the success but you can the solution if it happens to you. Getting to know about the Mindfulness is such a good thing for you to try and hopefully it can also be an effective solution for you.

That is actually such the skill or even capability which is helpful to let you improving lots of things in the life and makes everything getting its maximum achievement. Thus, you can be more, get much more, and even enjoy many more. Learning and practicing it can help you so much in dealing with lots of things as long as it has to be practiced regularly. Some of the benefits which you can obtain are getting the better physical health as like getting the better level of energy, well improved blood pressure, and so on. Other benefits which can also be obtained are getting the better health of the mental, better relationship, and so on. There is a bunch of good things which can be obtained then.

That is a good idea to go getting lots of info about the mindfulness and then try to learn it well and practice it regularly for getting the good result and benefits. Finding the professional therapist near me may be an essential thing to be considered so that we will get lots of good things, for example by going to MindfulnessMavericks.co.uk.

Invisalign-Only Specialist Boutique in Boston

There must be strong reason when your dentist recommended you to get teeth alignment. The structure of your teeth may not optimum and in long term it may cause a lot of problem. However, teeth alignment isn’t a small procedure. It can be really painful and it may take months or even years to complete. The biggest turn down would be that ridiculous braces you must wear. It can make you lose confident.

Fortunately, there’s a better alternative for those who are not confident wearing wire braces. It is called Invisalign, clear and removable aligner works as effective as wire brace. The clear structure makes it virtually invisible that most people wouldn’t notice you wear aligners. Invisalign also much comfortable and much hygienic to wear while it can offer more optimum result. If you are interested in getting Invisalign for teeth alignment in Boston, there’s one name highly recommended and that is Smilebar. Unlike other dental clinics offering Invisalign, Smilebar is the first Invisalign-only specialist boutique in Boston greater area ensuring it has the latest and most advanced Invisalign technology. Not only that, it has team of top leading orthodontic specialists with extensive expertise and experience as Invisalign provider.

What makes Smilebar different from other Invisalign providers? This boutique clinic has the most advanced 3D imaging technology to get patient’s detailed anatomical information for the orthodontics. It is including 3D scan of your teeth structure to determine the Invisalign plan for teeth alignment. This ensures the brace will be more precision and comfortable to wear. As a boutique clinic, Smilebar also offers very different atmosphere that the stereotype of old dentist office. It is designed to make you comfortable while waiting or while getting the treatment. So, there’s no more reason to hesitate. Contact Smilebar today and get a chance for a free consultation and 3D teeth scan.

Dental Health Is a Direct Connection to General Health

Not that long ago oral hygiene was not considered anything important to one’s overall general health. Dental health and oral hygiene is as important as other things in our body. Their proper functioning can avoid lots of complications and if a problem occurs, then many of the tasks be stopped.

Apart from adding up to your beauty and smile by maintaining your teeth, it is also important for your health as dirty and pale teeth can result in many complications like intestinal problems, stomach problems and more.

They can also look good and smell good, likewise if you have maintained them well. In order to look after your teeth well, your teeth be clean of germs and debris that can make them look faded and yellow. Your gums along with your teeth if perfectly healthy they should not bleed while brushing as unhealthy gums bleed as well as hurt. So, if your gums and teeth are in perfect health they won’t bleed, hurt or have any bad breath.

Brushing and Cleaning

Proper brushing is the fundamental step to take to have clean and healthy teeth. There are many people who are not aware of the basic steps in cleaning and brushing teeth. Brushing requires 2 minutes time and it is important that at least this amount of time is given. You should reach with the toothbrush all areas of your mouth and brush all the teeth, paying special focus on back teeth, corner teeth, around the gum-line teeth etc.

Teeth cleaning and brushing helps you to clean your teeth off debris, plaque and bacteria and to make them look shiny, sparkling and white. Brushing the teeth right means brushing up and down and not long site of teeth and gums. The up and down movement with the brush will allow the bristles of the brush in between the teeth to remove any food particles. This will prevent many teeth ailments like gingivitis, cavities or dental caries, periodontal ailments etc.

Toothpaste!

Selecting toothpaste at random is a problem and a health concern. Chemicals in toothpaste make many people sick, most of the time not realizing the connection. There be hardly any toothpaste you can find of the shelf that are chemical free.

To find a toothpaste that is one hundred percent free of artificial flavor, color, sugar, sweetener, and toxic chemicals would be almost as hard as picking the winning lotto numbers. There is one well-known brand name made in China; this one is even worse than most of the others. Stay well clear from it. Most people are not aware of chemical sensitivity and those with allergies, diabetes etc. what effect this can have.

Dental Health Does Affect General Health

Most of us understand that poor dental health can cause gum disease, gingivitis, mouth sores, buildup of plaque and tooth loss. It doesn’t stop here; bad oral hygiene can lead to many other serious health issues. We should not underestimate, oral health is about much more. It can cause cardiovascular disease and blood disorder. Bacteria from the mouth can get into the blood stream, cause infection spreading throughout the body. Infection of the gum can interfere with brain cells and lead to memory loss.

Because of inflammation caused from gum disease, this can trigger rheumatoid arthritis, which is painful and is a debilitating inflammatory disease. As well it can affect kidneys, blood pressure, bones and weaken the immune system. As bacteria travels through the bloodstream, it can cause respiratory infection and infect lungs causing bronchitis and pneumonia.

Some other studies and information claim that cancer is also triggered by root canal. Evidence shows when cancer patients get the root-canal removed the recovery rate, when treated for cancer, is by far greater and the patient gets better. Although, the cause of the problem shouldn’t be ignored and treated first, before treating the symptom. As with oral health, it’s a well-known fact that oral health affect’s much more than just your mouth. Inflammation in the gums or toxic pockets in the jaw can destroy the immune system almost completely.

4 Impossibly Simple Dental Hygiene Tips for Everyday

Everyone wants to have that fantastic toothpaste-model smile. Did you know that getting such a smile is not all that difficult? Sometimes all that is needed is to maintain high levels of oral hygiene. All dental problems- at least a majority of them- are as a result of poor dental care. These issues could be anything from gum disease, bone loss, heart disease and so much more. Checkups and proper hygiene can prevent these issues. Here are some simple dental hygiene tips that you can employ to ensure that you keep your teeth healthy for years to come. They are exactly what you know:

1. Brushing

This is one of the simplest ways of maintaining oral hygiene. If you are brushing your teeth, you need to place your brush at an angle of 45 degrees close the gum line. The gum line and tooth surface must be in contact with the bristles. On the outer surface of the teeth using a backward -forward, up-and -down motion, making sure to be done gently to evade bleeding.

In order to clean the inside surfaces of the teeth and gums, place the bristles at a 45-degree angle and repeat the backward forward, up-and-down motion. Finally, the brush surfaces of your tongue and the roof of your mouth to remove bacteria, which may lead to bad breath. Brushing your teeth twice a day helps you to curb buildup of bacteria. If you cannot do this, rinse your mouth with water after eating to reduce the amount of food that would serve as the home for the bacteria.

2. Flossing your teeth.

Flossing can help you remove food particles and other damaging substances that regular brushing of teeth cannot. It enables one to reach between the teeth where toothbrush bristles cannot reach or mouthwash can’t wash away. It is recommended that you floss your teeth once in a day.

3. Reduce tobacco intake

This will help your teeth a lot. First, it will save you from oral cancer and periodontal diseases. Second, it will put away all the many horrible side effects caused by agents used to mask the smell of tobacco. For instance, when you smoke a cigarette, you are highly likely to use candy, tea or coffee to mask the smoky breath and odor from getting out. This increases the harm created.

4. Use mouth wash apart from brushing and flossing

They are not important and not all are effective. They contain Listerine and carbon dioxide is very helpful because they help exterminate and preserve the bacteria in your mouth. Mouth wash can help sustain well-built teeth. However, mouth wash goes hand in hand with brushing, flossing, visiting the dentist and eating well, it is just the thing that will improve your dental strength and make it grand.

Everything You Need To Know About Cosmetic Clinics

Nowadays, numerous cosmetic clinics offer a lot more than regular facials and waxing. Non-invasive treatments are widely used to expel uneven pigmentation that has developed in the skin, undesirable hair, crow’s feet, wrinkles and spider veins, or even to provide fullness to your lips. However, it’s all about finding the best facility for you, and here are some suggestions that will help you find the right clinic for effective treatment.

Different Types Of Cosmetic Clinics

Remember, there’s a major contrast between a beauty facility that offers the standard services, for example, facials, scrubs, body wraps and hair expulsion, and cosmetic clinics that offer treatments with permanent results. The usual beauty facilities have trained beauticians that only offer regular skin treatments. On the other hand, cosmetic clinics offer services of experienced, qualified, and licensed surgeons who perform major cosmetic surgeries, offering multiple benefits.

Cosmetic clinics, then again, offer a wide range of permanent beauty solutions that improve not only beauty, but also health of the patient. These incorporate skin and laser procedures, so usually the staff and the surgeon must be fully trained to perform these major cosmetic procedures.

Generally, laser treatments have gain prominence in recent years because they offer a safe and financially savvy approach to improve beauty in various ways:

unwanted hair from different body parts such as bikini area, underarms, hands and legs can be removed permanently
freckles and sun spots are removed effectively
spider veins are permanently removed without any need of surgery and has zero discomfort

Cosmetic clinic also offers other skin treatments as well, for example Microdermabrasion, lip enhancement, and Botox treatment. Just make sure that the staff and surgeon is fully trained to perform these treatments.

The Most Effective Method To Pick The Best Cosmetic Clinic

A renowned cosmetic clinic that offers invasive, non-invasive, and surgical treatments should have a team of trained staff and a qualified surgeon. They are supposed to guarantee that all the treatments are performed accurately, give any anaesthetic medication if necessary, and first of all evaluate whether you are suitable to get the treatments or not.

Remove Unwanted Facial And Body Hair Using Laser Treatment

Removing unwanted hair is time-consuming and repetitive no matter what your preferred hair removal technique is, and whether you shave, pluck, wax, thread or use depilatory creams, the hair will always grow back. You’ll find the skin on your face is sensitive, and constantly using harsh hair removal treatments can cause a great deal of skin irritation.

All women have hair on the face, usually it’s fair and fine and is difficult to see, but those with darker hair are not so lucky. You will find that most of your female friends have the same issues when it comes to unwanted facial hair. The hair on the upper lip, chin, cheeks and sideburns can all be very embarrassing and cause you a great deal of insecurity. It seems that every time you think you’ve disposed of unwanted hair, you’ll find more of it sprouting up somewhere else, and even after you get rid of the hairs, they just grow back.

You can cover up your excess hair in areas that aren’t constantly exposed, but the hair on your face is always on display, and it can seem as though everyone is always looking at the hairs on your upper lip, chin or sideburns. A good way to get rid of unwanted hair is with laser hair removal.

Benefits of laser hair removal:

It permanently reduces hair safely
It’s a fast treatment time
The results will boost your self-confidence
Prevents razor bumps and irritation
Laser treatment causes only minimal discomfort

Laser energy gets absorbed by the pigment in the hair follicle, and this laser energy is then converted to heat, causing thermal damage to the follicle without harming the surrounding skin. This results in hair growth being stopped in the damaged follicle.

Generally for white skin you’ll need around 6 treatments, spaced 4-6 weeks apart, and this usually results in 80% of hair removal. Darker or black skin may need around 8 treatments, resulting again in 80% of hair removed.

Most clients experience minimal discomfort; some may experience a minor stinging or pinching sensation on the skin as we deliver the laser pulses, but we can offer topical anaesthetic cream to make treatments more comfortable.

Although we can perform laser hair removal treatment on white or black skin, lasers only work on hair which has pigment, because it absorbs the laser light and allows the heat to build up and diffuse throughout the follicle to destroy it. Therefore it’s not possible to treat white, grey, and blond hair by laser.

If you need help choosing a cosmetic procedure, we provide an extensive range of cosmetic procedures for the face and body: Botox, Vaser Lipo, Lip Augmentation, Dermal Fillers and many more treatments, to help create a younger, slimmer, more youthful looking you!

Clinical Trial Budgeting and Technological Impact

The current clinical trial and drug regulatory process have lagged behind advances in scientific research. Regulatory approval is based on the evidence of efficacy and safety gathered from pivotal trials. Most experts agreed that traditional approach to drug development constitute a blunt tool where a more focused experiment could suffice instead of a one-size-fits-all approach which is ineffective and wasteful.

According to studies conducted by New England Journal of medicine, almost nine in ten clinical trials do not meet FDA requirement and thus do not reach the market. Project fails when they do not meet endpoints. Lack of efficacy and complex protocol are the major cause of failure. To reverse this trend, productivity must be directed towards the poor predictive capability of the current experimental model.

Clinic trial plays a major role in drug development and advancement in technologies such as drug positioning, therapeutic target, and drug efficacy prediction are helping researchers and pharmaceutical companies in drug development.

Traditional trials have fixed parameter that is determined in advance and remain constant throughout out the process. One promising approach to modernizing clinical trials and maximizing efficiency is by adaptive trials which allow for certain parameters such as sample size and treatment regimen to be modified or replace on interim results.

The major hurdle is that investment in clinical research is dwindling as government and stakeholders tightened their budgets. As major sponsors revenue stabilize and cost continue to rise, the clinical trial finds itself in a financial squeeze. Pharmaceutical and medical-device companies have been intent on trimming budgets. Lean contract negotiations are the norm these days, no sponsor is walking around with money burning hole in their budget and most are responding to mandate to save cost by requiring CROs to provide unrealistic competitive budgets which are disastrous. With tightened budget, short-sightedness has become the order of the day and as a result, both sponsors and CROs reputation suffered.

Cutting back drastically or unwillingness to adequately fund a project will produce a poor result. This simplistic strategy is unrealistic and unsustainable. It is important to note that focusing solely on short-term strategy will be detrimental in the long-term. If sustainable research climate is created, prosperity will definitely grow.

There has been increasing effort in utilizing technologies to streamline protocol and boost efficacy in clinical research. The use of technology is empowering research professionals by helping them to make a decision based on resulting data. With the aid of technology, organizations are reducing cost and speeding up evaluation process. Technology allows for accrual of data faster and that information can be disseminated in real time. This can lead to a better decision being made on protocol, patient recruitment, and trial sites.

Here is the list of technologies impacting clinical trials today

Risk Based Monitoring (RMB)

Companies use risk based monitoring to target and prioritize resources, identify risks relating to quality, safety of subjects and integrity of clinical trial data. Risk based monitoring (RMB) can incorporate targeted monitoring or triggered monitoring and reduced source document verification (SDV).

Traditionally, source data verification (SDV) were conducted 100% via on-site monitoring, a labor intensive approach. Reduced SDV limits the measure of SDV at the site, study and subject level.

The quest for more key ways to manage clinical trials has distinguished risk based monitoring which attempts to manage resources without compromising on clinical quality.
The variables of protocol compliance, data integrity, and patient safety etc. impact how assets are deployed.

The impact of technology in risk based monitoring is profound and currently in markets are clinical trial management systems (CTMS) and remote data capture (RDC) which can support risk based monitoring system. Some systems still support manual entering and reporting of clinical trial data, for this reason, there is a need to setup more robust systems for flagging and alerting data automatically, these alerts can be developed for notifying those who need to act when an issue arises.

According to Medidata, the cost of onsite monitoring is approximated at 28.7% of study budget and project management at 26.47%. In moving to RMB, monitors can spend their time more judiciously and reduce cost.

Electronic Trial Master File

In biopharma industry, every organization involved in clinical trial maintains a trial master file containing several thousand pages of regulatory documents needed for each clinical trial.

Using a paper-based or hybrid trial master file system to manage thousands of clinical documents, processes and tasks can be overwhelming and can cause errors or misread that can ruin clinical trial and put it at risk for noncompliance.

Organizations usually employed an Enterprise Content Management System (ECM) to manage clinical trial regulatory documents. The ECM based eTMF offers automated methods to index, archive, and report on documents and content.

To eliminate paper from a clinical trial study, electronic signing utilizing digital signatures from verified users is being employed. Globally, most countries including the US and many countries in EU are accepting digital signatures in place of wet signatures thereby eliminating the need for scanned documents.

An electronic trial master file (eTMF) offers a robust platform to document management which allows study team members to gain a quick insight necessary to efficiently manage clinical trials and speedup time to market. Electronic document management processes are being adopted at a steady pace as it becomes vital to business productivity, shortened biopharma product development timelines, and cost cutting.

eSource

In 2013, the FDA release its Guidance Document on Electronic Source Data in Clinical Investigations, since then sponsors and study sites have been adopting and employing eSource as a method of recording data in clinical trials.

The definition of electronic source (eSource) is a clear concept — to capture or process source data electronically, this data exclude the source data that was captured on paper and transcribed into an electronic database. In eSource, the source data element itself must be electronic.

The benefit of eSource is apparent and the FDA endorsed it because it will be useful in: facilitating real-time entering of electronic source data during subject visits, removes the need to duplicate data, allows for accuracy and completeness of data by using electronic prompts for inconsistent and missing data and lessens the chance for transcription errors.

The need to modernize and streamline the way data is collected are evolving, as a result, much of the exploratory done thus far by several pharmaceutical companies have been mostly to build internal competency. In moving forward, it is critical that standards and interoperability within different eSource modalities come together to help create systems that provide accurate data in clinical research.

Using Clinical Data Repository (CDR) to drive optimization

The ability to effective manage, report and analyze data is of paramount importance in clinical trials. The major hurdle is that data from clinical trials are frequently entered by clinicians electronically or manually across multiple channels including EDC, LIMS, CDMS and IVRS and other systems each with unique underpinning needs. This approach causes data to end up in different databases making it complex and time-consuming to leverage and synchronize the data.

There is confusion as to what constitute or defines CDR as distinct from a clinical data warehouse (CDW). CDR can be thought of as consolidated storage and transfer of data for clinical trials including security, workflow, and systems for performing daily task all under one umbrella.

Centralization of the storage and management of data results are the purpose of CDR and to provide a steadfast and reliable infrastructure that supports clinical data analysis and management, facilitate standardization and secure transfer of data, allow for analytics and cross-trial analysis and to leverage data from trials across the pipeline.

Concierge Medicine + TeleMedicine = Way To Go!

More and more doctors are considering adding telemedicine and concierge medicine business models to increase revenue streams and improve patient services. Many are finding that educating patients about the benefits of telemedicine as a cost-effective, hassle-free care delivery model is the best approach to increasing adoption rates.

Armed with smartphones, patients can schedule a same day appointment for both minor and major conditions. Doctors find telemedicine provides opportunities to consult with peers and specialists in the cloud to make faster, more accurate decisions – sometimes life saving decisions, such as identifying signs of a stroke or imminent heart attacks during virtual patient encounters.

Why TeleMedicine?

Telemedicine allows patients access to faster appointments, often immediately or on the same day as the first request. Physicians can spend quality one-on-one time with patients and personalize health care without traveling to an office or clinic.

Doctors can now offer problem-focused visits for everything from a follow up for prescription renewals to highly complicated situations where a patient has multiple medical conditions and many providers. Virtual collaboration makes it more convenient to discuss potential drug contraindication with all providers using a secured digital platform.

Patients can reach their trusted physician from anywhere, anytime, even when they are traveling for business or vacation. There is no need to see another doctor if either is out of town. And, non-emergency issues – colds, dermatitis, ear pain, etc – can often be handled with a short virtual visit instead of waiting for an office visit.

Technology empowers physicians to monitor at-risk patients while giving patients more tools to control blood pressure, glucose levels and other health metrics from the comfort of their homes.

Telemedicine plus concierge medicine provide a dual solution. Patients can speak to and see a trusted doctor every time they have a problem. While virtual visits don’t allow doctors to actually listen to the heart or lungs or take a throat swab, it is possible to make a well-informed decision about when to request the patient come in for a visit. Concierge medicine ensures patients have access to a trusted group of provider when an in-person visit is the best answer. The combination is convenient, affordable and provides continuity of care necessary to build patient confidence.

What We Eat Mentally Affects Our Physical Body

With the onslaught of globalisation and instant communication people are absorbing the evils of the world at a greater rate than ever before. Where once there was time to think about what we took in mentally it is now almost unnoticeable as it can happen in a second or less. Television, the Internet, and smart phones are occupying our time while flashes of information pass before our eyes as sparks in the universe.

Every spark has the potential to start a fire in the compost of our dreams. They can outweigh emotions and send us on a tangent that is completely different to the path we were on. Unless we are strong enough mentally to ward them off we will fall victim to the aim of their makers.

This is what the world has become. It is ruled by an insanity of dreams, conflicts, make-believe, and their consequences. It is governed by the things designed to pull us apart mentally and test our resolve to reconnect with our roots.

What am I talking about? The best explanation concerns my reincarnation and link to the Universal Spirit. It fills all of space and is in each one of us driving and guiding us to our end. Not one has independent thought or actions but we are a collecting body of the forces of creation.

Some have been chosen and are led in a different manner because of their link to the Spirit. They neither lie nor can accept lies. They ward off the sparks of make-believe and earthly ideals like water from a duck’s back. They are content and peaceful enough in their ways that only the Almighty can stir them into action.

Others, however, are like pins on a bowling alley Anything that strikes them will be a hit. They take in the filth of the world and they absorb the sparks to warm their cockles. They treat others as fodder and many will destroy in a pitch for greatness.

The question is, therefore, why has God made humans to be so diverse in nature, character, and behaviour. The answer lies in the plan laid down from the start to bring some to the glory of spiritual power and they are growing in a garden of weeds, prickles, and rocks to test them.

“For they prophesy a lie unto you, to remove you far from your land, and that I should drive you out, and ye should perish.” Jeremiah 27:10

This is what has happened to the world. Lies, make-believe, and sparks of unsubstantiated lights are driving people away from reality. Only those strong enough to withstand them are growing with strength and will be there are the harvest.

3 Steps for Women In Medicine To Have A Stress-Free Day

For women in medicine there are many things we have to accomplish each day before our first patient encounter. That means we spend most of our time reacting to what’s happening instead of being intentional. This is not the goal for doctors, nurse practitioners, or nurses who want to avoid stress, worry, frustration and feeling out of control. When you are intentional, you decide in advance the qualities you desire for your day. Rather than succumb to the stress of heavy traffic on your commute, worrying about arriving to work on time, and the number of patients scheduled for the day, you can set an intention to have a day of ease and flow. My clients understand the importance of staging your day. Here’s what I mean:

1. Before you leave work the night before, get a handle on what is on your schedule for the following day. What’s on your calendar that must be done? What are the priorities for the next day? What is on the schedule that is not essential for you to do that you can delegate to someone else on your team? From this vantage point you will focus on the items that are most important. This not only decreases stress, it lets you use your time more efficiently. Mapping out the next day gives you some room to breathe.

2. When you wake up, set clear intentions about your day before you even leave home so that your commute to the hospital or office is easy, effortless and stress free. If you are a woman in medicine with a family, you have experienced the stress of managing more than one schedule at a time. You may be juggling your spouse’s deadlines and your children’s activities in addition to your own. It is easy to feel overwhelmed when you are the primary organizer in your home. Identify how you want to feel as you move throughout you day and then declare it. When you are feeling out of sorts, remind yourself of your morning declaration.

3. Once you get to work, I recommend that my clients spend 5 minutes setting an intention – this is before reviewing email, checking patient charts, or responding to a colleague. It is the first thing you do when you get to the office. Once you’ve completed that step, it is time to meet with your team. Start the team meeting by taking 5 minutes to set a team intention. What are you working on? What do you need from me? What will you commit to doing today?